Impact of High Level of Lipoprotein(a) on Myocardial, Hepatic Remodeling and Carotid Arteries Plaque Formation: A Magnetic Resonance Study

Recent studies have linked high lipoprotein(a) levels to atherosclerotic cardiovascular disease (ASCVD) and calcified valvular aortic stenosis (VAS). About 1 in 5 individuals have elevated Lp(a) levels. High Lp(a) levels are risk factors for ischemic heart disease, peripheral artery disease, heart failure, cardiovascular mortality, and all-cause mortality. Fatty liver disease (FLD) is a prevalent metabolic liver disease with a strong association with cardiovascular disease. Non-invasive diagnostic methods like computed tomography, magnetic resonance imaging, and MR spectroscopy are commonly used to diagnose FLD. This study aims to investigate the influence of serum Lp(a) levels on hepatic T1-times using magnetic resonance imaging. The study aims to explore the link between elevated Lp(a) levels and myocardial remodeling and oxygenation in patients with elevated Lp(a), as well as the association between elevated Lp(a) and carotid artery plaque formation and hepatic steatosis.